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KMID : 0043319900130030240
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Archives of Pharmacal Research
1990 Volume.13 No. 3 p.240 ~ p.245
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Synthesis of 1,4-Dihydropyridine Derivatives with Vasodilating Activities(I)
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Suh JJ
Lee BY/Kim CS/Lee JW/Kim BC/Han BH/Kim CS
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Abstract
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Asymmetric 2,6-dimethyl-4-aryl-1,4-dihydropyridine-3,5-dicarboxylate with [N-(3,4-methylenedioxybenzyl)-N-methyl] aminoethyl group as the ester moiety and related 1,4-dihydropyridine derivatives were prepared and tested for the effects on vascular smooth muscles. 2,6-dimethyl-4-(3’’-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[N-(3’’,4’’-methylenedioxybenzyl)-N-methyl] aminoethyl ester 5-methyl ester (11) and 2,6-dimethyl-4-(3’-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[N-2’’,3’’-methylenedioxy-benzyl)-N-methyl] aminoethyl ester 5-ethyl ester (15) showed potent vasodilating activities. IC50 (10-8M) was 2.6 and 2.7 for 11 and 15, compared with 3.5 for nicardipine.
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KEYWORD
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